pentobarbital will reduce the extent or result of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Powerful or average CYP3A inducers could decrease cobimetinib systemic publicity by >80% and lower its efficacy.
benzhydrocodone/acetaminophen and pentobarbital both enhance sedation. Avoid or Use Alternate Drug. Limit use to individuals for whom option treatment possibilities are inadequate
pentobarbital will minimize the extent or outcome of ziprasidone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
pentobarbital will lower the level or impact of cilostazol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will lower the extent or result of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will decrease the extent or effect of tamoxifen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will decrease the extent or result of buspirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
MAOI extend the effects of barbiturates in all probability mainly because metabolism on the barbiturate is inhibited.
pentobarbital will lessen the extent or impact of doxorubicin liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will reduce the level or outcome of nitrendipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
Drug dependence to barbiturates arises from repeated administration of the barbiturate or agent with barbiturate-like effect on a steady foundation, frequently in quantities exceeding therapeutic dose check here amounts. The traits of drug dependence to barbiturates include:
Keep an eye on Carefully (one)pentobarbital will minimize the level or influence of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Warning when discontinuing CYP3A4 inducers which are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may well improve and may lead to possibly deadly respiratory despair.
pentobarbital will lower the level or impact of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lower the extent or influence of phenytoin by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Keep an eye on.